Zoe Walker (née Hanna; born 23 August 1974) is a senior consultant in emergency medicine who worked in the emergency department of Holby City Hospital from 2007 to 2016. She arrived in the department at the end of 2007, and became Clinical Lead in 2013, before stepping down from the position the following year.

Upon arriving at the ED, Harry Harper was the Clinical Lead. After Harry's resignation, Zoe and Maggie went head-to-head for the job. Zoe eventually got offered the job, but resigned in 2008 after Maggie's departure. Nick Jordan took over just weeks later, and Zoe and Nick bonded closely, and even had a brief relationship between 2009 an 2010. When his partner, Yvonne Rippon, was taken away to a specialist spine clinic as a result of injuries she sustained during the Holby riots, Nick decided to leave temporarily leaving Zoe as acting Clinical Lead. He returned to the ED with her temporarily in 2013, before making the permanent decision to quit, therefore giving Zoe the permanent position.